منابع مشابه
Interleukin-1 Promotes Repair of the CNS
1Curriculum in Neurobiology and the University of North Carolina Neuroscience Center, 2Department of Pathology and Laboratory Medicine, and 3Department of Microbiology and Immunology, and the Program of Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, North Carolina 27599, and 4Department of Internal Medicine and Howard Hughes Medical Institute, Washington Univers...
متن کاملPerineuronal Nets and CNS Plasticity and Repair
1Department of Neuroscience, Neuroscience Institute of Turin (NIT), University of Turin, 10100 Turin, Italy 2Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), Regione Gonzole 10, Orbassano, 10043 Turin, Italy 3Netherlands Institute for Neuroscience (NIN), 1105 BA Amsterdam, Netherlands 4John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University o...
متن کاملNeural Stem Cell Approaches to CNS Repair
Neural stem cells (NSCs) can self-renew and give rise to neurons, astrocytes and oligodendrocytes. NSCs are found in the central nervous system (CNS) of mammalian organisms, and represent a promising resource for both fundamental research and CNS repair. Animal models of CNS damage have highlighted the potential benefit of NSC-based approaches. Here we review the progress in the field of NSC bi...
متن کاملThe Role of Peripheral CNS-Directed Antibodies in Promoting Inflammatory CNS Demyelination
In central nervous system (CNS) demyelinating disorders, such as multiple sclerosis (MS), neuromyelitis optica (NMO) and related NMO-spectrum disorders (NMO-SD), a pathogenic role for antibodies is primarily projected into enhancing ongoing CNS inflammation by directly binding to target antigens within the CNS. This scenario is supported at least in part, by antibodies in conjunction with compl...
متن کاملBeyond Clotting: A Role of Platelets in CNS Repair?
Platelets are small, oval, circulating, anucleate cells that upon endothelial damage form a haemostatic plug and stop blood leakage. Circulating platelets derive from bone-marrow-resident megakaryocytes that daily produce and release approximately 100 billions of new platelets into the blood stream (Kaushansky, 2006; Semple et al., 2011). During haemostasis, tethering platelets adhere to the va...
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ژورنال
عنوان ژورنال: Science
سال: 2016
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aag3327